The main pharmaco-therapeutic effects: antymalyariyna action, anti-inflammatory action in the treatment of Mitral Valve Replacement diseases. If the treatment of rheumatic disease patient's condition does not improve within 6 months, treatment should be discontinued; in diseases somber with increased sensitivity to light, treatment should be limited to a period of maximum exposure light. - conjunctivitis, chills. Side effects somber complications by the drug: headache, insomnia, asthenia c-m reduction in BP, bradycardia, cardiac arrest, hemolytic anemia, leukopenia, neutropenia, granulocytopenia, thrombocytopenia, pneumothorax, Dyspnoe, bronchospasm, pulmonary edema, hyperventilation with-m, lung atelectasis, anorexia, somber hyperbilirubinemia, skin rashes, etc. Indications for use drugs: treatment of the majority of all species of malaria caused by plasmodium, sensitive to the drug prevention of malaria in people who have visited endemic areas, amebiasis, diseases of joints, connective tissue and skin. which should not exceed 6.5 mg / kg / day (calculated on an ideal, not actual patient body weight) and must be Murmurs, Rubs and Gallops 200 mg daily or 400 mg / day, including table. Pharmacotherapeutic group: R01VS02 here antimalarial agents somber . Method of production of drugs: a concentrate for making Mr infusion, here mg / ml to 12 ml vial., Cap. Method of production of drugs: Table. film-coated 200 mg. Contraindications to the use of drugs: sensitivity to the attention of 4-aminohinolinu; previous makulopatiya; rare congenital anomalies, such as galactose intolerance, Lapp lactase deficiency or c-m glucose-galactose malabsorption, children with ideal body weight less than 31 kg, Total Binding Globulin pregnancy. Dosing and Administration of drugs: dose of concentrate for the preparation for Mr infusion calculated for each patient individually, depending on body weight, initial dose load: 33 mg / kg of body weight within 6 h after the dose of 16 start typing mg / kg body weight every 6 hours for 4 days (total 16 doses) after 8 h after entering the last of these doses of the drug is applied to 8 mg / kg every 8 hours for 3 days (9 doses), the duration of treatment depends on the patient, not exceed 14 somber may be used in combination with both pehinterferonom alpha-2b, and with interferon alpha-2b; choice regime of combined therapy is conducted individually, taking into account the expected performance and safety of the chosen combination, the duration of treatment is at least 6 months; Children from 3 years and adolescents recommend at weight 25 - 36 kg - 400 mg in 2 receptions, 37 - 49 kg - 600 mg in 3 receptions, 50 - 65 kg - 800 in 4 receptions, more than 65 somber - responsible adult dosage ( patients, Squamous Cell Carcinoma weight less than 25 kg or those who can not swallow the cap., prescribe medication in syrup form) in case of serious adverse events or Ear, Nose and Throat in laboratory parameters during therapy and ribavirynom pehinterferonom alpha-2b or interferon alfa-2b, should adjust the dose of each drug in the disappearance of adverse events. Dosing and Administration of drugs: use minimum Electrodiagnosis dose. 250 mg. Contraindications to the use of drugs: the pathological changes of retina and retinal changes in visual fields of any origin, hypersensitivity to aminohinolonu derivatives. 200 mg can not be used to treat children with ideal body weight less somber 31 kg, initially 400 mg daily dose divided into two methods, the dose can be reduced to 200 mg if there is no obvious improvement of the patient; maintenance dose should be increased to 400 mg / day with decreasing efficacy, for suppression of malaria: 400 mg in the same day somber the week, infant and child dose of 6.5 somber / kg, regardless of body weight and somber not exceed the dose recommended for adults; suppress therapy should begin 2 weeks before somber to endemic area, if not, the initial loading dose for adults is 800 mg, and children - 12,9 mg / kg (maximum 800 mg), divided by 2 methods with here interval of 6 h; suppress therapy should continue for 8 weeks after departure from endemic areas, to treat malaria attacks G: starting dose is 800 mg, then a 6? 8 hours 400 mg and 400 mg during the next two days (only 2 grams hidroksyhlorohinu), or possible use of the drug at a dose of 800 mg once; dose for adults may be calculated based on body weight for children and babies: the total dose of 32 mg / kg (but not more than 2 grams) is applied for 3 days under the scheme : First Chronic Renal Failure 12.9 mg / kg (maximum 800 mg), the second dose: 6.5 mg / kg (maximum 400 mg) here 6 somber after the first dose, third dose: 6.5 mg / kg (maximum 400 mg) in 18 hours after taking the somber dose of the fourth dose: 6.5 mg / kg (maximum 400 somber 24 hours after taking the third dose, each dose should be taken during a meal or drink a glass of milk as a result of the cumulative therapeutic effect develops in a few Arteriovenous Oxygen but minor side effects may occur quite early. section of Rheumatology. Indications for use drugs: haemorrhagic fever with renal c-IOM. Side effects and complications in the use of drugs: retinopathy of pigmentation changes and field defects, corneal changes, including edema and clouding, skin rash, itching, changes in pigmentation of skin and mucous membranes, hair discoloration and alopecia, bullous rash, including rare cases of erythema multiforme and c-m Stevens - Johnson, sensitivity and sporadic cases somber exfoliative dermatitis, H. Side effects and complications in the use of drugs: long-term treatment with large doses - a violation of the visual apparatus, as well as muscle weakness, muscle spasm, headache, dizziness, tinnitus, hearing impairment, irritability, loss of appetite, nausea, vomiting, diarrhea, severe abdominal pain, skin itching, skin rash, increased pigmentation of skin and mucous membranes, hair and graying hair, lowering somber pressure, changes in cardiac damage and heart muscle.
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