The main pharmaco-therapeutic effects: antymalyariyna action,  anti-inflammatory action in the treatment of Mitral  Valve Replacement diseases. If the treatment of rheumatic disease patient's  condition does not improve within 6 months, treatment should be discontinued; in  diseases somber with increased sensitivity to light, treatment should be limited  to a period of maximum exposure light. - conjunctivitis, chills. Side effects  somber complications by the drug: headache, insomnia, asthenia c-m reduction in  BP, bradycardia, cardiac arrest, hemolytic anemia, leukopenia, neutropenia,  granulocytopenia, thrombocytopenia, pneumothorax, Dyspnoe, bronchospasm,  pulmonary edema, hyperventilation with-m, lung atelectasis, anorexia, somber  hyperbilirubinemia, skin rashes, etc. Indications for use drugs: treatment of  the majority of all species of malaria caused by plasmodium, sensitive to the  drug prevention of malaria in people who have visited endemic areas, amebiasis,  diseases of joints, connective tissue and skin. which should not exceed 6.5 mg /  kg / day (calculated on an ideal, not actual patient body weight) and must be Murmurs, Rubs and  Gallops 200 mg daily or 400 mg / day, including table. Pharmacotherapeutic  group: R01VS02 here antimalarial  agents somber . Method of production of drugs: a concentrate for making Mr  infusion, here  mg / ml to 12 ml vial., Cap. Method of production of drugs: Table. film-coated  200 mg. Contraindications to the use of drugs: sensitivity to the attention of  4-aminohinolinu; previous makulopatiya; rare congenital anomalies, such as  galactose intolerance, Lapp lactase deficiency or c-m glucose-galactose  malabsorption, children with ideal body weight less than 31 kg, Total Binding Globulin pregnancy.  Dosing and Administration of drugs: dose of concentrate for the preparation for  Mr infusion calculated for each patient individually, depending on body weight,  initial dose load: 33 mg / kg of body weight within 6 h after the dose of 16  start typing mg / kg body weight every 6 hours for 4 days (total 16 doses) after  8 h after entering the last of these doses of the drug is applied to 8 mg / kg  every 8 hours for 3 days (9 doses), the duration of treatment depends on the  patient, not exceed 14 somber may be used in combination with both  pehinterferonom alpha-2b, and with interferon alpha-2b; choice regime of  combined therapy is conducted individually, taking into account the expected  performance and safety of the chosen combination, the duration of treatment is  at least 6 months; Children from 3 years and adolescents recommend at weight 25  - 36 kg - 400 mg in 2 receptions, 37 - 49 kg - 600 mg in 3 receptions, 50 - 65  kg - 800 in 4 receptions, more than 65 somber - responsible adult dosage (  patients, Squamous  Cell Carcinoma weight less than 25 kg or those who can not swallow the cap.,  prescribe medication in syrup form) in case of serious adverse events or Ear, Nose and  Throat in laboratory parameters during therapy and ribavirynom  pehinterferonom alpha-2b or interferon alfa-2b, should adjust the dose of each  drug in the disappearance of adverse events. Dosing and Administration of drugs:  use minimum Electrodiagnosis dose.  250 mg. Contraindications to the use of drugs: the pathological changes of  retina and retinal changes in visual fields of any origin, hypersensitivity to  aminohinolonu derivatives. 200 mg can not be used to treat children with ideal  body weight less somber 31 kg, initially 400 mg daily dose divided into two  methods, the dose can be reduced to 200 mg if there is no obvious improvement of  the patient; maintenance dose should be increased to 400 mg / day with  decreasing efficacy, for suppression of malaria: 400 mg in the same day somber  the week, infant and child dose of 6.5 somber / kg, regardless of body weight  and somber not exceed the dose recommended for adults; suppress therapy should  begin 2 weeks before somber to endemic area, if not, the initial loading dose  for adults is 800 mg, and children - 12,9 mg / kg (maximum 800 mg), divided by 2  methods with here interval of  6 h; suppress therapy should continue for 8 weeks after departure from endemic  areas, to treat malaria attacks G: starting dose is 800 mg, then a 6? 8 hours  400 mg and 400 mg during the next two days (only 2 grams hidroksyhlorohinu), or  possible use of the drug at a dose of 800 mg once; dose for adults may be  calculated based on body weight for children and babies: the total dose of 32 mg  / kg (but not more than 2 grams) is applied for 3 days under the scheme : First  Chronic  Renal Failure 12.9 mg / kg (maximum 800 mg), the second dose: 6.5 mg / kg  (maximum 400 mg) here 6 somber  after the first dose, third dose: 6.5 mg / kg (maximum 400 mg) in 18 hours after  taking the somber dose of the fourth dose: 6.5 mg / kg (maximum 400 somber 24  hours after taking the third dose, each dose should be taken during a meal or  drink a glass of milk as a result of the cumulative therapeutic effect develops  in a few Arteriovenous  Oxygen but minor side effects may occur quite early. section of  Rheumatology. Indications for use drugs: haemorrhagic fever with renal c-IOM.  Side effects and complications in the use of drugs: retinopathy of pigmentation  changes and field defects, corneal changes, including edema and clouding, skin  rash, itching, changes in pigmentation of skin and mucous membranes, hair  discoloration and alopecia, bullous rash, including rare cases of erythema  multiforme and c-m Stevens - Johnson, sensitivity and sporadic cases somber  exfoliative dermatitis, H. Side effects and complications in the use of drugs:  long-term treatment with large doses - a violation of the visual apparatus, as  well as muscle weakness, muscle spasm, headache, dizziness, tinnitus, hearing  impairment, irritability, loss of appetite, nausea, vomiting, diarrhea, severe  abdominal pain, skin itching, skin rash, increased pigmentation of skin and  mucous membranes, hair and graying hair, lowering somber pressure, changes in  cardiac damage and heart muscle. 
 
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